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KMID : 0363220230610020140
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Korean Journal of Dermatology
2023 Volume.61 No. 2 p.140 ~ p.142
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Excited Skin Syndrome after Patch Testing in a Patient with Atopic Dermatitis Treated with Dupilumab
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Lee Mi-Young
Kim Young-Jae
Lee Woo-Jin
Chang Sung-Eun
Lee Mi-Woo
Won Chong-Hyun
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Abstract
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The effect of dupilumab on allergic contact dermatitis or patch testing is unknown. Here, we present a case ofexcited skin syndrome that appeared after patch testing during dupilumab treatment. A 21-year-old woman presentedwith atopic dermatitis that showed only a partial response to cyclosporine and dupilumab. A patch test wasperformed to check for underlying allergic contact dermatitis. The result was consistent with excited skin syndrome.
Some studies argue that dupilumab suppresses allergic reactions triggered by allergens that activate the Th2 pathway.
Others suggest that it does not affect the result of patch testing, regardless of the type of allergen tested. Even ifdupilumab suppresses a certain allergic or immunologic pathway, this case shows that it cannot mask excited skinsyndrome on patch testing.
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KEYWORD
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Atopic dermatitis, Dupilumab, Patch tests
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