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KMID : 0363320020230010041
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Journal of Korean Oriental Internal Medicine
2002 Volume.23 No. 1 p.41 ~ p.46
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The Effects of Gamisachi-tang on the Serotonin Contents in Separate Brain Region of Mice Immobilized by Stress
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Hong Yi-Sil
Jeon Chan-Yong
Park Jong-Hyung
Han Yang-Hee
Kim Dong-Woo
Park Se-Ki
Choi You-Kyung
Baek Eun-Ki
Han Jhee-Wan
Ha Kyung-Sik
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Abstract
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Background and Objectives : This experimental study was conducted to evaluate an anti-stress effect of Gamisachi-tang(加味四七湯) on mice immobilized by stress.
Methods : The experimental animals were immobilized by stress for 15 minutes, and administered 9mg/20g or 18mg/20g of Gamisachi-tang(加味四七湯) extract for seven days before they got stressed. The serotonin contents in the frontal cortex, hypothalamus, corpus striatum, hippocampus were measured by HPLC method in rat brain.
Results : In frontal cortex, serotonin contents significantly decreased in both sample A and B group compared to the controlled group. In the hypothalamus, serotonin contents increased in both sample A and B group compared to the controlled group. In the corpus striatum, serotonin contents significantly increased in both sample A and B group compared to the controlled group. In the hippocamous, serotonin contents significantly increased in both sample A and B group compared to the controlled group.
Conclusions : According to the above results, Gamisachi-tang(加味四七湯) had a significant impact on the changes in serotonin contents, which occurred in a separated part of mouse brain caused by stress.
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KEYWORD
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Gamisachi-tang(加味四七湯), serotonin contents, immobilization stress, brain region
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