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KMID : 0364219760190020071
Korean Journal of Zoology
1976 Volume.19 No. 2 p.71 ~ p.78
Effects of Thymidine Anologs on Methyl Methaesulfonate Induced Chromosome Aberrations in Human Lymphocytes in Vitro
Kang Yung-Sun

Park Sang-Dai
Choi Kyung-Hee
Abstract
Chromosome aberration induced by methyl methanesulfonate (MMS) and the effects of thymidine analogs (BUdR or IUdR) on MMS-induced chromosome aberration were studied in human lymphocyte cultures. Single treatment with MMS to lymphocytes induces both chromatid and chromosome type aberrations with high frequency of chromatid type. The combined treatment of BUdR or IUdR with MMS was found to be more effective in increasing the rate of chromosome type aberrations.
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