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KMID : 0364219890320040351
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Korean Journal of Zoology
1989 Volume.32 No. 4 p.351 ~ p.357
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Effects of Alcohol on the Ultrastructures of Rat Liver
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Kim Jeong-Ok
Hah Jae-Chung
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Abstract
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To investigate the effect of alcohol on the ultrastructural changes of liver the experiment was undertaken by dividing in 3 groups (control, alcohol and alcohol-camitine groups). Chronic administration of ethanol to adult rats led to striking fat accumulation and ultrastructural changes in the liver. Mitochondrial abnormalities. dilation of endoplasmic reticulum, focal cytoplasmic degradation, dilation of bile canalicli and swelling of nucleus were observed. In alcohol-carnitine group, there were less fat accumulation and ultrastructural changes than alcohol group. These alterations suggest that ethanol is very toxic to the liver and carnitine prevents fat accumulation induced by alcohol.
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KEYWORD
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Ethanol , Carnitine , Ultrastructre , Rat liver
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