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KMID : 0364219900330020158
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Korean Journal of Zoology
1990 Volume.33 No. 2 p.158 ~ p.165
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Alterations in the Level of Calpain During the Differentiation of Chick Embryonic Muscle Cells in Culture
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Kwak Kyu-Bong
Chung Sung-Soo
Park Hye-Gyeong
Kim Hye-Sun
Chung Chin-Ha
Ha Doo-Bong
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Abstract
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Proteolytic activity of calpain was found to increase as myoblast fusion proceeds. At 60 hr after cell seeding, lis activity reached to a maximal level and then slighdy decreased thereafter. Similarly, the protein level of calpain reached to a maximal level just proir to the initiation of fusion and remained elevated upon prolonged culture as analyzed by immunoblol using anti-calpain antiserum. These results suggest that the synthesis of calpain is regulated during myogenesis and its proteolytic activity may be related with the process of myoblasts fusion.
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KEYWORD
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Calpain, Myoblast, Cell fusion
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