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KMID : 0364820100460020219
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Korean Journal of Microbiology
2010 Volume.46 No. 2 p.219 ~ p.222
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Evaluation of Vi-Passive Hemagglutination, SD® Kit, and Widal Test for Serological Diagnosis of Typhoid Fever
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Kim Sung-Hun
Kim Shuk-Ho
Lee Deog-Yong
Lee Esther
Park Mi-Sun
Lee Bok-Kwon
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Abstract
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In this study, we evaluated Vi-passive hemagglutination (Vi-PHA), SD Salmonella Typhi IgG/IgM (SD® kit) and Widal test for the rapid laboratory diagnosis of typhoid fever patients. A total of 36 serum samples from febrile patients in Korea from 2005 to 2006 were used. Among 36 patients, 27 were fever patients without typhoid, 9 were typhoid fever. Vi-PHA showed 8 positive results out of 9 typhoid fever patients (sensitivity 88.9%) and 1 positive and 26 negative results out of 27 febrile
patients without typhoid (specificity 96.3%). The sensitivity and the specificity of SD® kit were 100% and 92.6%, respectively. However, the sensitivity and the specificity of Widal O & H tests were 88.9%, 100%, and 77.8%, 70.4%, respectively. Consequently, Widal H and SD® kit showed higher sensitivity and Vi-PHA showed higher specificity. To efficient diagnosis, Vi-PHA may be sufficient diagnosis method in acute cases and SD® kit and Widal test may be sufficient in sporadic area and high risk group.
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KEYWORD
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serological diagnosis, SD kit, typhoid fever, Vi-PHA, Widal test
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