KMID : 0366919930050010020
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Sungkyun Pharmceutical Journal 1993 Volume.5 No. 1 p.20 ~ p.24
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The Chemotherapeutic Effect of Double-stranded RNA
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Abstract
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The synthetic, double-stranded RNAs including polyriboinosinic: polyribocytidylic acid (poly I : C)exert a wide diversity of biologic effects which has been shown at both the cellular and organism levels. Poly I : C is effective in vitro in inducing resistance to virus infection in a variety of cell types and in activating the cytotoxic potential of macrophages. In addition, poly I : C is a potent macrophage or NK cell activator and interferon inducer, which is effective in the prophylactic and therapeutic treatment of viral infections and in the therapy of tumor. Thus synthetic ds RNA can be utilized as a therapeutic agent, either alone or in combination with interferon.
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