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KMID : 0369919970120000033
Journal of Pharmaceutical Sciences (C.B.N.)
1997 Volume.12 No. 0 p.33 ~ p.43
Preparation and Evaluation of Yellow Beeswax Matrixes of Nalidixic Acid


Abstract
Yellow beeswax matrixes of nalidixic acid for slow release medication was prepared, and evaluated in vitro and in vivo test. Agg A(core: matrix=1.5:1.5g) and Agg B (core: matrix=2.4:0.6g) were made by modification of Kawashima¡¯s liquid stspension method. For these products, dissolution test was conducted, and then, blood nalidixic acid concentration of oral Agg A was compared with that of nalidixic acid suspension.
The results are as follows:
1) The order of dissolution rate constants (K_s) was Agg B>nalidixic acid powder> Agg A.
2) Absorption fraction (F) and absorption constant (K_6) of Agg A were more decreased than those of nalidixic acid suspension, but blood nalidixic acid concentration of Agg A was sustained significantly.
From these facts, it was considered that yellow beeswax matrixes of nalidixic acid for slow release medication have some possibilities in practical application.
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