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KMID : 0371620080230010001
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Journal of Wonkwang Medical Science
2008 Volume.23 No. 1 p.1 ~ p.6
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The relevance of serial C-reactive protein and functional prognosis of patients with acute ischemic stroke
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Lee Myung-Hee
Park Sung-Hee
Park Hyun-Young
Chang Hyuk
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Abstract
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Background: Recent studies showed that elevated C-reactive protein(CRP) level was independently related to long-term outcome after ischemic stroke. We investigated the short term outcome-related serial CRP levels in patients with acute ischemic stroke.
Methods: A total of 66 subjects(28 men, 38 women), who had undergone admission, between July 2005 and November 2005, were included in this study. Serial CRP measurements were done within 12 to 24 hours(CRP 1), within 48 hours(CRP 2), and at 14 days(CRP 3) after symptom onset by high sensitive assay. Chinical outcomes were measured at 90 days by the Barthel index(BI). We examined the association between their values and the clinical outcomes and we adjusted the possible confounding factors using Spearman’s correlation analysis.
Results: Of 66 patients, 21 patients showed poor clinical outcomes(BI＜85). The poor clinical outcome was related with age(P=0.029), total cholesterol(P=0.004), LDL-cholesterol(P＜0.0001), leukocytes counts(P=0.001), frequency of large artery atherosclerosis(P=0.011), NIHSS(P＜0.0001), CRP 1,2,3 levels(P＜0.0001). In Spearman’s correlation analysis, CRP 1 level(R=0.779; P＜0.001), CRP 2 level(R=0.764; P＜0.001), and CRP 3 level(R=0.765; P＜0.001) were related with poor clinical outcome after 90 days of ischemic stroke onset.
Conclusion: Serial CRP levels had relation with 90 days poor clinical outcome. The CRP level measured within 12 to 24 hours after symptom onset of ischemic stroke is better related to short-term outcome.
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KEYWORD
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C-reactive protein, prognosis, ischemic stroke
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