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KMID : 0371919900030010107
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Journal of Wonju College of Medicine
1990 Volume.3 No. 1 p.107 ~ p.114
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Abstract
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recently the dexamethasone suppression test (DST) and TRH stimulation test (TST) are the major neuroendocrinologic parameters to evaluate and identify depressive disorders. Depression, especially some of major depression is known to have HPA and/or HPT axis dysfunction. There has been some reports about the discriminating neuroendocrine measurement for various type of depression including some depressive equivalent psychiatric syndromes.
The authors measured diurnal cortisol test (DCT), DST and TST for groups of depression proper, depression spectrum and non-depression psychiatric disorders to find out any differences between them. The patient subjects were 68 inpatients in Wonju Christian Hospital, Wonju Medical College, Yonsei University from Jan. 1990 who didn´t meet exclusion criteria.
The results were as below;
1) By DCT, distortion of diurnality was found in 3 cases of depression proper and 11 patients, distributed in all 3 groups, were found hypersecretor of cortisol.
2) By DCT, 10 cases from both depression groups showed abnormal response, whether the response was late escape, inadequate suppression, or no suppression. All the patients from non-depression showed normal response.
3) By one-way ANOVA, mean serum cortisol in both depression groups was found significantly increased at one time compared to non-depression group. There was no differences between both depression groups.
4) The patient with DST non-suppression was found more in both depression groups (13/38) than non-suppression. Between both depression groups, more patients from depression spectrum (7/16) than from depression proper (6/22) were non-suppressor.
5) Between each 3 groups there was no difference in the level of mean baseline TSH and TSH after TST.
6) Rate of TST blunting response was 38.8% in depression proper and 36.4% in depression spectrum, and it accounted 2 times higher in both depression groups (11/29) than non-depression group (4/22).
7) By both DST and TST test the diagnostic sensitivity of depression reached 72.4%. Especially for patients with depression spectrum, 10 from 11 subjects showed abnormal response by either one test.
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KEYWORD
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