This study was aimed at chacking whether tri-iodinated compounds with greater solubility and oow osmolality, Na or meglumine ioxaglate(Hexabrix 320, Guerbet Lab., France) has nephrotoxicity .
Subjects were 21 children admitted to our hospital for the evaluation of their congenital heart diseases. None of them had any evidence of renal dysfunction before thd study. They were devided into 2 group, one was low-dose group(Hexabrix
give,
<2.0ml/kg) and the other one was high-dose group(?2.ml/kg). Renal funciton studies including serum creatinine(Scr), fractional excretion of sodium(FENa) and urinary 2-microglobulin exrection(UBME, mg.of 2-microglobulin
per
gm
creatinine) were done before and after Hexabrix administration.
@ES Statistical analyses were done using paried t-test and Wilcoxon signed rank test, Results were as follows:
@EN 1. There were no significances of Scr and FENa between before-and after-Hexabrix study.
2. There were significant differences of UBME before-and after-Hexabrix study.
3. Comparing 2 gorups, high-dose and low-dose group, with regard to UBME, there was significant increase of UBM in high-dose group after Hexabrix study but not in low-dose group.
4. Uric acid and/or calcium oxalate crystaluria appeared after Hexabrix administration.
In conclusion, we confirmed that Hexabrix 320 could induce renal injury, particularly proximal tubular dysfunciton, in recommended dosages for cardiac evaluation and that was dose dependent.
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