KMID : 0374920110320010065
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Inje Medical Journal 2011 Volume.32 No. 1 p.65 ~ p.71
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A Case of Agranulocytosis due to Re-exposure to Antithyroid Agent in a Patient with Relapsed Graves' Disease
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Kim Seung-Man
Kim Tae-Young Park Su-Young Bae Young-Hwan Seo Young-Kyeong Jung Eun-Joo Kim Tae-Kyoon Kwon Min-Jeong Park Jeong-Hyun Lee Soon-Hee
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Abstract
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Agranulocytosis, one of the major side effects of antithyroid a gents, probably occurs in less than 0.25% of cases treated with antithyroid agents. It usually occurs within the first several weeks or months after the initiation of therapy, when drug dosage is higher. Most reported cases of agranulocytosis have occurred during the first 3 months of therapy. We describe here a rare case that did not experience the side effect for 6 years of antithyroid agent treatment but presented with agranulocytosis in one month after re-exposure. It suggests that the major side effect such as agranulocytosis can occur in patients who had undergone prior uneventful antithyroid drug therapy.
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KEYWORD
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Agranulocytosis, Antithyroid agents
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