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KMID : 0376219700070030391
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Chonnam Medical Journal
1970 Volume.7 No. 3 p.391 ~ p.400
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The autonomic innervation of the urethra in the rabbits. Responses of the isolated urethral strips to some autonomic drugs.
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Abstract
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Anatomically, the urethra is a tubular structure innervated with the autonomic nerve acid the somatic nerve the urethra receives sympathetic fibers from the hypo gastric nerve and parasympathetic fibers from the pelvic nerve and the external sphincter of the urethra is solely innervated by somatic fibers from the internal pudic nerve. However, the physiological significance of the autonomic innervations is not clearly understood. According to the recent literatures, it is suggested that urethra is not only a urine passage connected to the urinary bladder but also it plays an important role for the micturition reflex. In the present studies effects of some autonomic drugs on the isolated urethral strips were examined to-investigate the functional significance of the autonomic, nerve distributed to the urethra. The results are as follows:
1. A marked contraction of the isolated urethral strips was observed by administration of either norepinephrine or epinephrine, and this effect was abolished completely by pretreatment of; phenoxybenzamine or regitine, the adrenergic ?-receptor blocking gents whereas the effect was not affected by pre treatment of dichloroisoproterenol, an adrenergic ?-receptor blocking agent.
2. A marked contraction of the isolated strips was demonstrated by the administration of acetylcholine and this effect was abolished by pretreatment of atropine, a cholinergic blocking agent.
3. These observations suggest that the urethra is innervated by the adrenegic effect and cholinergic nerve fibers and that the adrenegic receptors in the urethra is of type.
4. Responses of the isolated urethral and detrusor muscles to acetylcholine were similar each other and such observation suggests that the urethra may act synergistically to the contraction of detrusor muscle in micturition.
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