|
KMID : 0376219800170020553
|
|
Chonnam Medical Journal
1980 Volume.17 No. 2 p.553 ~ p.557
|
|
|
Changes in Serum Concentrations of 3, 3´, 5´ -Triiodothyronine(Reverse T₃) During Pregnancy.
|
|
|
|
|
Abstract
|
|
|
Serum concentrations of 3,3´, 5-triiodothyronine (T3), reverse T3 (rT3) and thyroxine (T4) were measured in normal pregnant women at each trimester of pregnancy and immediately after delivery and compared with those of cord blood.
The rT3s values rose progressively in each trimester and reached the value 2.2-fold higher than the values of normal non-pregnant controls. after delivery_ The T3levels were not significantly different from the control values although slightly decreasing tendency was noted during pregnancy. Immediately of ter delivery, however, the T3 levels markedly increased to the value 2-fold higher than the controls. The T4 levels were elevated 200% above the non-pregnant control values in each trimester and decreased slightly after delivery but still maintained the values higher than the controls. The cord blood showed a markedly elevated rT3 with decreased T3 level, although the T4 levels were not changed from the normal adult values.
These results suggest that the elevated serum rT3 levels without concomitant change in T3 levels during pregnancy could be caused by the inhibition of 5-deiodinase activity. It is also suggested that different regulatory mechanisms for thyroid hormone metabolism operate in pregnant woman and fetus.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|