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KMID : 0376219850220020319
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Chonnam Medical Journal
1985 Volume.22 No. 2 p.319 ~ p.326
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Influences of Steroid on Hair Cells of the Corti´s Organ after Exposure to Intensive Noise
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趙容範/Jo, Yong Bum
鄭立秦/張寅源/Chung, Ib Jin/Chang, In Won
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Abstract
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Relationship between loud noise and hearing loss has been recognized for hundreds of years. Recently, it has been regarded as a serious problem since we are frequently exposed to the harmful noises and these noises can cause a irreversible damage to the hair cells of Corti´s organ
Many methods have been developed in managing the noise-induced hearing loss, but no definite method is yet available.
The purpose of this experiment is to observe the influences of steroid on the hair cells of Corti´s organ after exposure to intensive noise, the corticosteroid used here being dexamethasone. The guinea pigs were treated with dexamethasone for one week after exposure to the noise of jet engine aircraft.
Cytocochleograms useful in describing the incidence of pathologic´ hair cells were made with the surface preparation technique. The following results were obtained:
1. In control group, not treated with dexamethasone, displacement of the hair cell nuclei was observed in the basal, second turn, and the beginning part of the apical turn; most severe in upper part of the basal turn and lower part of the second turn.
2. Incidence of the pathologic hair cells in control group was high in upper part of the basal turn and beginning part of the second turn, and decreased in the apical turn.
3. Pathologic changes of the outer hair cells were more severe than the inner hair cells in the control group.
4. Displacement of the hair cell nuclei in dexamethasone treated group was less irregular than in control group.
5. In dexamethasone treated group, the incidence of pathologic findings such as swelling, pycnosis, and karyolysis, was slightly decreased.
6. Pathologic hair cells in the outer hair cells were more frequently observed in the outer row than in the middle and inner row.
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