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KMID : 0376219920290010097
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Chonnam Medical Journal
1992 Volume.29 No. 1 p.97 ~ p.104
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Morphometric analysis of the liver cell dysplasia
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Abstract
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In order to evaluate the characteristic features of liver cell dysplasia, morphometric analyses of the nuclear and cytoplasmic areas were made in liver cell dysplasia, hepatocellular carcinoma, nondysplastic cirrhosis, and normal liver, and the
data
obtained were compared with each other.
1. In liver cell dysplasia, hepatocellular carcinoma, nondysplastic cirrhosis, and normal liver, the nuclear areas were 63.0±26.1μ㎡, 35.2±9.5μ㎡ and 31.3±7.6μ㎡, and the nucleo-cytoplasmic ratios were 0.186±0.060, 0.236±0.076,
0.143±0.043,
and 0.137±0.039, respectively.
Liver cell dysprasia had he mean nuclear area as large as hepatocellular carcinoma and had the largest mean cytoplasmic area. The nucleo-cytoplasmic ratio, subsequently, is more akin to that of normal liver rather that of hepatocellular
carcinoma.
2. Coefficient of variation of the nuclear areas, which indicated size variation, was largest(42.1%) in liver cell dysplasia, even larger than that of hepatocellular carcinoma.
Form factor, a parameter of shape variation, was 0.914±0.056 in liver cell dysplasia. It was in between 0.894±0.071 of hepatocellular carcinoma and 0.937±0.060 of normal liver.
From these results, it is evident that liver cell dysplasia has morphometric features intermediate between those of hepatocellular carcinoma and normal liver, and is assumed to be a precancerous lesion.
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KEYWORD
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