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KMID : 0376419820060010083
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Chonbuk University Medical Journal
1982 Volume.6 No. 1 p.83 ~ p.88
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Leakage of Adrenoceptor Antagonists from the Lateral Ventricle to the Blood Stream in the Rabbit.
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Abstract
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It was attempted in this investigation to find out whether or not several alpha- and betaadrenoceptor antagonists injected intraventricularly :teak and reach to the systemic circulation in anesthetised rabbits.
1. When given intraventricularly(i, vt.) alpha-ads-enoceptor antagonists, yohimbine and piperoxan, produced pressor effect but when given intravenously(i, v.) they elicited transient depressor response.
2. I, vt. yohimbine, phenoxybenzamine and phentolamine did not affect the. pressor effect of i, v. norepinephrine (NE) but their i, v, administration inhibited the effect of NE. Prazosin and thymoxamine, given either by i, vt. or i, v. , inhibited the effect of NE.
3. When given i.vt, beta-adrenoceptor antagonists, practolol and sotalol did not affect the cardioaccelerator and depressor effects of i, v. isoproterenol (ISP) but when given i, v. practolol inhibited the cardioaccelerator effect and sotalol attenuated the depressor effect of ISP respectively. dl-Propranolol and pindolol, given either by i, vt, or i, v. , inhibited both effects of ISP.
4. Both i, vt. and i, v, d-propranolol did not affect the both effects of ISP.
5. These results indicate that i, vt, prazosin, thymoxamine, dl-propranolol and pindolol leaked into the systemic circulation.
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