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KMID : 03772197919790000061
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Medical Journal of Chosun Univercity
1979 Volume.4 No. 1 p.61 ~ p.70
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Studies of the liver disease on the cellulose acetate electrophoretic fractions of the serum proteins
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신태호/Shin, Tae-Ho
이형동/김창세/Lee, Hyung-Dong/Kim, Chang-Se
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Abstract
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Cellulose acetate electrophoretic fractions of serum proteins were performed and the following results were obtained:
1) The mean values for the electrophoretic fraction of serum proteins in control groups (normal) were 3.29±0.6gm/100㎖ (48.36±6.65%), 0.22±0.09gm/100㎖ (3.49±1.32%), 0.76±0.23gm/100㎖(10.58±2.87%), 0.99±0.20gm/100㎖ (14.38±3.27%), and 1.50= 0.34gm/100㎖ (21.28±4.64%), respectively, for the albumin, α_1-, α_2-,β-, and γ-glo-bulin fractions.
2) The mean values for the electrophoretic fractions of serum proteins in liver cirrhosis group were 2.41±0.46gm/100㎖ (34.11±8.27%) 0.28±0.15gm/100㎖ (4.06±2.19%), 0.64±0.24gm/100㎖ (9.08± 3.67%), 1.00±0.34gm/100㎖ (14.08±4. 23%), and 2.74±0.99gm/100㎖(38.78±9.91%), respectively, for the albumin, α_1-, α_2-,β-, and γ-globulin fractions. It was also found that the changes observed in liver cirrhosis were more marked than in control group particularly other forms of liver disease-the most charac-teristic abnormalities being decreased concentrations of albumin and increased concentra- tions of γ-aglobulin.
3) The mean values for the electrophoretic fractions of serum proteins in heptitis group were 2.67±0.76gm/100㎖ (41.95±10.43%), 0.30±0.15.gm/100㎖ (4.60±2.62%), 0.73±0.28gm/100㎖ (11.19±4.35%), 0.88±0.36gm/100㎖(14.03±4.33%), and 1.74±0.55gm/100㎖ (27.51±6.11%), respectively, for the albumin, α_1-, α_2-,β-, and γ-globulin fractions. It was found that the decreased concentration of albumin observed in hepatitis was more marked than in control group.
4) The mean values for the electrophoretic fractions of serum proteins in hepatoma group were 2.66±0.58gm/100㎖(38.04±8.92%), 0.31±0.13gm/100㎖(4.53±2.39%), 0.75±0.31gm/100㎖(10.79±3.68%), 1.11±0.46gm/100㎖(16.00±5.43%), and 1.96±0.63gm/100㎖ (28.73±8.13%), respectively, for the albumin α_1-, α_2-,β-, and γ-globulin fractions. It was found that decreased concention of albumin and increased concentration of γ-globulin fractions in hepatoma were more marked than in control group.
5) The mean values for the electrophoretic fractions of serum proteins in cholecystopa- thy group were 2.55±0.65gm/100㎖(40.63±11.56%), 0.25±0.14gm/100㎖(4.13±2.03%), 0.82±0.25gm/100㎖(12.69±3.49%), 0.97±0.31gm/100㎖(14.75±3.21%), and 1.77±0.75gm/100㎖(27.25±9.51%), respectively, for the albumin, α_1-, α_2-,β-, and γ-globulin fractions. It was found that the decreased concentration of albumin in cholecystopathy was more marked than in control group.
6) The mean values for the electrophoretic fractions of serum protins in liver abscess group were 2.36±0.43gm/100㎖(35.27±5.06%), 0.58±0.28gm/100㎖(8.38±3.43%), 0.98±0.36gm/100㎖(l4.38±4.89%), 0.95±0.29gm/100㎖(13.69±3.12%), and 1.83±0.71gm/100㎖ (27.15±8.40%), respectvely, for the albumin, α_1-, α_2-,β-, and γ-globulin fractions. It was found that decreased concentration of albumin and increased concentration of α_1-globulin fractions were marked than in control group.
7) All of the clinical chemistry data, so-called liver function tests, were shown the increased concentrations except cholesterol. Most chracteristic findings were the increased concentration of serum potassium observed in liver cirrhosis and hapatoma groups.
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