Àá½Ã¸¸ ±â´Ù·Á ÁÖ¼¼¿ä. ·ÎµùÁßÀÔ´Ï´Ù.
KMID : 0377219850100010063
Medical Journal of Chosun Univercity
1985 Volume.10 No. 1 p.63 ~ p.70
Studies on the Superoxide dismutase Activity in the Cytosolic Fractions of the liver and Spleen of Gamma-Irradiated Mice




Abstract
Superoxide dismutase(SOD, superoxide : superoxide oxidoreductase, EC 1.15.1. 1) is a nnetalloprotein ubiquitously present in all aerobic living cells. At present, three types of SOD : copper and zinc-contain ing(Cu, Zn-SOD), manganese-containing(Mn-SOD) and iron-containing(Fe-SOD) enzyme have been isolated fromboth eultaryotic and prokaryotic cells. As, a scanvenger¢¥ of superoxide radicals in biological tissues, these metalloenzymes are undoubtedly of importance in the protection of living organisms against the effect of highly toxic superoxide radicals. A variety of biologically important processes are accompaied by formation of these radicals, but they can also generated by some exogeneous factors, for example, by ionizing radiation. The present paper report the results of experiments dealing with SOD activity in the cytosolic fraction of the liver and spleen of nice exposed. to 400R whole-body irradiation. The whole-body irradiation caused a decrease in the specific activity of SOD in the both liver and spleen which persist more than 21 days.
KEYWORD
FullTexts / Linksout information
Listed journal information