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KMID : 0377220080330040026
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Medical Journal of Chosun Univercity
2008 Volume.33 No. 4 p.26 ~ p.30
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Purification and Antibiotic Activity Studies of the Antimicrobial Protein from Human Amniotic Fluid
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Park Sung-Chul
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Abstract
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An Antimicrobial protein was isolated from human amniotic fluid through dialysis, ultrafiltration, and C18 reverse-phase high performance liquid chromatography. This protein, which we named AMPAF, antimicrobial protein from amniotic fluid, possessed antimicrobial activity but no hemolytic activity. This protein inhibited pathogenic microbial strains, including Candida albicans and Listeria monocytogenes. Tricine gel electrophoresis revealed that the molecular mass of AMPAF was about 20 kDa. These results suggest that the AMPAF is an excellent candidate as a lead compound for the development of antifungal agents
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KEYWORD
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antimicrobial protein from amniotic fluid Amniotic (AMPAF), antimicrobial activity, pathogenic microbial strains, antimicrobial agent
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