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KMID : 0377619640060020145
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Korean Jungang Medical Journal
1964 Volume.6 No. 2 p.145 ~ p.155
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A Trial with Dehydroemetine hydrocnloride (Ro 1-9334) in Paragonimiasis in Korea
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임영찬/Lim, Y. C.
柳浩濬/金應瑞/金元一/李炫/朴柄宰/蘇鎭卓/Yu, B. J./Kim, E. S./Kim, W. I./Lee, H./Park, B. J./Soh, C. T.
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Abstract
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44 cases of paragonimiasis were admitted in 121 Army Hospital for the clinical trial with the drug, dehydroemetine hydrochloride. Dehydroenietine hydrochloride was administered to 19 cases with the doses of 1 mg/kg of body weight/day for 10 days, and second course of 13 day administration was followed after 12 day rest.
The remain of cases were applied as control group for emetine-HCI, astiban, and 5% glucose solution. The result of the trial are summarized as follows;
1) 15 out of 19 cases showed decrease of E.P.D. (egg per day) after the second course. 3 converted. to egg negative and 5 showed complete disappearance of blood sputum.
2) Three cases showed radiological improvement in X-ray picture.
3) Blood pressure, red cell sedimentation rate, and white blood cell count became worse at the beginning of the administration of the drug in several cases with short duration, then continued to be with in the normal range of their values until after the second course.
4) Electrocardiographic changes were very slight in several cases, but recovered to normal in 1-´2 weeks after the administration of the second course.
5) Systemic side effects were practically absent.
6) No improvement of symptoms was observed in 2 cases administered with astiban, 3 cases with emetine-HCI, and 20 cases with 5% glucose as control.
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