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KMID : 0377619670130020177
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Korean Jungang Medical Journal
1967 Volume.13 No. 2 p.177 ~ p.189
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Experimental Studies on the Influence of Vitamins Upon Antibody Formation in the Rabbit
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Abstract
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It has been shown earlier that some vitamins exert no distinct influence over the formation of immune bodies in animals, but that some others play an important role in the immune reactions. In view of the scanty reports available in this field the author tried in the present paper to confirm and establish the effects of vitamins on the formation of immune bodies in adult male rabbits.
The animals were randomly chosen among those in the range of 2kg. in their body weights, and vitamins A, B1, B6, folic acid, C,D, and E were administered, accompanied by injection of a horse serum as an antigen. As an analytical measure, the pyroninophilic cell, the appearance of which is believed to be a function of the formation of immune bodies, in spleen and lymphnodes was studied with the following results.
(1) The pyroninophilic cell in spleen and lymphnodes appeared more in the vitamin-administered than the normal rabbits, though the difference was of little magnitude among the two, and could not exceed the number of the cell appeared after simple immunization. The appearance of the cell in the vitamin-administered rabbits was the most eminent with the vitamin B6, followed by B1, A, D, E, and C in a decreasing order.
(2) Administration of the vitamins with the concurrent injection of the immune serum to the animals made the pyroninophilic cell to appear more abundant in spleen and lymphnodes as compared to the appearance of the cell in the same tissues brought by simple immunization alone. The degree of the cell appearance as affected by the vitamins was the most pronounced with B6 and followed by the effects with B1, A, folic acid, D,E, and C in order with less effects.
(3) There was a general tendency that the transient lymphocytes were more prevalent then the typical plasma cells among the pyroninophilic cells appeared in spleen and lymphnodes of the animals administered with the vitamins and injected concurrently with the immune serum.
(4) It is concluded from the above results that the administration of each of the vitamins A, B1, B6, folic acid, C, D, and E in an appropriate amount can bring a positive effect on the experimental formation of immune bodies in the animals.
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