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KMID : 0377619720220040461
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Korean Jungang Medical Journal
1972 Volume.22 No. 4 p.461 ~ p.464
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Effect of Hypophysectomy on Measurement Mast Cells of the Rat
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Lee Kap-Jae
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Abstract
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Mature male Swiss albino rats, weighing about 200gm each, were divided into groups of normal, hypophysectomy, and sham operation, and the hypophysectomized group was further divided into five subgroups of 1-, 2-, 3-, 5-, and 7-postoperative days. The authors then observed the number as well as the structure of the mast cells in the mesentery with the following results:
1. In the normal group, the number of mast cells appearing in the mesentery was on an average 32.73 per view field of 160X, about 7. 3 percent of which were degranulated cells.
2. In the group of sham operation, the average number of mast cells and the ratio of that of degranulated cells was similar to the value in the case of the normal group.
3. In general, in the group of hypophysectomy no marked change was observed in the number of mast cells, and only the 7-day subgroup showed a significant decrease(17%). The marked change was increase in the number of degranulated cells and this number increased with the lapse of time, finally reaching, in the 7-day subgroup, the level twice as large as that of the normal group. In addition, the shape of a cell took a somewhat irregular form with the passing of time. Furthermore, the size of granules in the cytoplasm became uneven, and the stain ability turned from metachromatic to orthochromatic, showing weak staining in general. Vacuolation was observed to increase.
4. To sum up the above, it can be concluded that the mast cells in the mesentery are not affected in number by hypophysectomy, but undergo notable structural changes due to this operation.
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