|
KMID : 0377619750290020167
|
|
Korean Jungang Medical Journal
1975 Volume.29 No. 2 p.167 ~ p.176
|
|
|
Metabolic Effects of Serine Dehydratase Induced by Hydrocortisone in Intact and Isolated Perfused Liver of Rats
|
|
Cho Moo-Yun
Kim Je-Hyun
|
|
|
Abstract
|
|
|
Hepatic serine dehydratase was induced with 5 mg of hydrocortisone by intraper-itoneal administration in albino rats weighing around 200 gm. Serine metabolism was observed in intact and in the isolated perfused liver. The results were as follows:
1) Serine dehydratase activity was two times higher in the hydocortisone treated group than in the controls in intact and in the isolated perfuse liver.
2) In vivo experiments blood concentrations of pyruvate was lower in the hydrocortisone group than in the control, whereas respiratory14CO2 was no dif￢ference between hydrocortisone and control groups.
3) In the isolated perfuse liver:
i) net cumulative production of pyruvate in the hydrocortisone group was less than that of the control in group after 200mg and 1. 2gm administrations of L-serine to each. group.
ii) net cumulative production of glucose after 200mg administration was lower in the hydrocortisone group than that of the control. This lower value was maintained until the end of the perfusion. After administration of 1. 2gm serine glucose production was continuously raised but no difference between the hydrocortisone and control groups was observed.
iii) liver glycogen content in the hydrocortisone group was higher than that of the control but there is no difference after administration of different dosages of L-serine.
From the above results it may be concluded that induced serine dehydratase activity was not parallel to the production of pyruvate, glucose, respiratory CO2 and liver glycogen.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|