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KMID : 0377619760310040357
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Korean Jungang Medical Journal
1976 Volume.31 No. 4 p.357 ~ p.366
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Experimental Studies on the Hepatic Changes Induced by Intestinal Bypass and Starvation
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Abstract
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The problems of obesity have become discussed increasingly nowadays and many trials such as diet control or surgical attempt of jejuno-colic bypass or ileo-jejunal bypass have been performed to correct obesity by lowering body weight.
Those surgical trials are successful in lowering body weight, but they can induce imbalance of metabolism and electrolytes by reduction of surface area of nutritional absorption.
It is easily suspected that those imbalance may cause the changes in various organs.
A comparative study was made on histological changes of´ liver and hematochemical changes by inducing nutritional disturbance and disturbance of absorption of rabbits by various methods.
Experimental evaluation was made on a total of 61 of experimental -animals weighing from 1.80kg to 2.45kg, of body weight divided in to 4 groups.
1) Group 1; control group consisted of 15 rabbits, with jejuno-colic adhesion.
2) Group 2; consisted of 15 rabbits, starved completely.
3) Group 3; consisted of 15 rabbits, jejuno-colic anastomosis performed.
4) Group 4; methionine and choline, given intramuscularly in doses of 3mg/kg daily, consisted of 16 rabbits.
Among 5 healthy rabbits selected from group 1, 2, and 3, blood sampling was done by 3 days interval and liver biopsy was taken with varying intervals. The results are as follow;
1) There was little difference in comparison with pre-expression with pre-experiments of pathohistological feature of liver cells, body weight, and hematoehemical change of 15 control rabbits performed jejuno-colic adhesion.
2) The fatty degeneration of liver of the rabbit, group of complete starvation state began to be noted 5 days after starvation and there were noted cellular infiltration of liver and hepatic cell necrosis on hepatic tissue sample 8 to 12 days alter starvation. Average life span of rabbits was 9 days and decreasing rate of body weight was 30.3% and this showed prominent reduction in comparison with control group.
3) The average life span of 15 rabbits performed jejuno-colic anastomosis was 14 days and increases in comparison with starvation group. There was gradual reduction of body weight and tissue findings of the liver after 12 days showed fatty infiltration and necrosis like a group 2 of complete starvation.
4) Methionine and choline lipotropic factors was given intramuscularly in doses of 3 mg/kg daily on 8 rabbits of starvation and 8 rabbits performed jejuno-colic anastomosis.
The fatty degeneration of these began to be noted after 7 days in comparison with starvation group and after 4 days in comparison with group of bypass procedure,
There were prolongation of average life span and gradual reducation of body weight.
It may be suspected by the influence of lipotropic agents.
5) Summing up these changes in blood chemistry, blood glucose and calcium level which showed within normal range in control group become to decrease in the group of completely starved and jejuno-colic bypass and potassium level decreased in jejuno-colic bypass group and increased in starved group.
Protein and sodium in both groups remained in normal range.
To summarize above experiments, it is certain that long termed nutritional deficits and disturbances of absorption of rabbits by starvation and bypass procedure induce fatty degeneration of liver cells, hepatic necrosis and hematological change.
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