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KMID : 0378019600030020053
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New Medical Journal
1960 Volume.3 No. 2 p.53 ~ p.84
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The Experimental Studies on the Influences of the Ovary upon the Allergic Changes in the Uterus
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Abstract
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´It is the clear fact that the cyclical changes of endometrium occurs under the control of the ovary physiologically.
It has been well known that the endocrine glands have close relationships of synergic or antagonistic, depressive or stimulative in a certain organ.
There are very closed : relationshPs between the ovary and the uterus physiologically.
The experiment has been planned to study the influences which the ovary. Would give on the allergic changes .in the uterus of the, rabbit.
Material and Method
Helthy adult female rabbits weighing around 2kg and young weighing around 1kg were used for this experiment and fresh horse serum were gives as an sensiting antigen.
The rabbits were divided into two groups of the adult and the young. Each group were subdivided into five groups which consist of normal, the ovarioctomizes, the autotransplantated, in which autotransplantation of the ovary was performed after castration, estrogen and progesterone administrated after castration and subdivided furthely into the sensitized and non-sensitized.
Among the unsensitized, one group was given do-se of 0.1 cc/kg of horse serum into the myometrium and the uterine cavity.
Among the sensitized; the sensitization, has been carried out by the injection of a dose of Ice/kg of horse. Serum in the inner region of the thigh hypodermically for 4 days.
The non-sensitized, and sensitized animals were sacrificed at. The end of 3,,6,13, 24, 48, 72 hours and 1, 2 weeks after the final injection. The section were prepared by Iiematoxylin-Eosin, Van Gieson stainsa and were submitted for histological examination.
Results
It was demonstrated that the ovary had the following influences on the allergic changes of the uterus induced by the injection of normal horse serum.
Grossly the removed uterus showed swe id congestion and petechiae.
The most intense findings of these changes were observed at 12 hrs∼ 48 hrs and subsided gradually in 72 hrs∼ lweek.
The above changes were aggraviated in sensitized groupe more than in nonsensitized group and, appeared more seriously in estrogen and progesterone group than in normal group and the allergic changes in the ovariectomized and autotransplanted groupes were milder than in those of normal group.
Microscopically the sensitized normal group showed the vascular dilatation and congestion, dilatation of uterine gland, thrombosis, fibrinoid dgeneration of vessels, swelling of connective tissue. Hemorrhage, infiltration of inflammatory cells mainly nentrophiles, lymphocytes and eosinaphiles, edema and hydroptic degeneration in the uterine glandular epithelium, and dilatation of the uterine glandullar lumen, which became worse at 12 hrs∼48 hrs and subsided gradually in 1-2 weeks. The above findings in sensitized normal group were much more intense than in nonsensitized normal group.
In ovariectozniied group, the allergic chages in the uterus were much less in intensity than those in the normal control group.
In the group of ovariectomised and the ovary autotransplanted, the allergic changes were found as in the control group, but the intensity of the changes was less pronounced than the normal group.
In the group of estrogen administered, the most intense allergic changes were observed and the changes appeared early in 6 hours and subsided lately in 1 week.
In the group of progesterone administered, the allergic changes showed moderately intense findings and were more pronounced than normal control, but less intense than estrogen administered group.
The results in the young female rabbit group were the same as in the adult group in general, but the allergic changes in each group, young rabbits showed less intense findings than in each groups of adult female groups.
Conclusion
The ovary enhances the allergic changes of the uterus.
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KEYWORD
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