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KMID : 0378019610040120067
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New Medical Journal
1961 Volume.4 No. 12 p.67 ~ p.75
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Experimental Studies on the Influence of Steroid Hormones to Experimental Dermatitis
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Abstract
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It is known that endocrine glands act an important rule of body metabolism and living processes, in this
meaning to clarify the influence of endocrine glands especially of steroid hormones upon various injuries in living body has become a recent target subject.
In this paper, the influence of various steroid hormones upon the experimentally induced allergic dermatitis with 2-4-dinitrochlorbenzene (DNCB) on the adult rabbit skin is discussed.
Rabbits, approximately 2 kg in weight, are used for the, animal study. For sensitizing,´ 0.2cc of 20 times normal saline diluent of 1% DNCB´alcohol solution is injected intracutaneously daily for 7 days. 0.1 cc of -the same antigen is reinjected into same area to induce the allergic changes in both control and steroids administered groups of rabbits for, a week after sensitization.
The animals studied are divided into 5 groups as follows;
1) Control group of normal rabbits.
2) Group in which cortisone is administered.
3) Group in which ACTH is administered.
4) Group in which testosterone is administered.
5) Group in which estrogen is administered.
The skin is examined macroscopically and microscopically, in 3, 12, 24, 48, 72 hours and 1 week after the reinjection respectively.
SUMMERY:
1) Cortisone exerts marked inhibitory effects upon the induced inflammation of the rabbit skin than the any other steroid hormones.
2) ACTH is acting inhibitory, too, as cortisone. But that effect appears to be somewhat weaker in comparison with cortisone.
3) Testosterone shows an inhibitory effect, which is weaker than cortisone but stroger than ACTH.
4) Estrogen has a less marked accelerating effect upon the allergic changes, differing with the reports of other authors.
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