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KMID : 0378019650080110079
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New Medical Journal
1965 Volume.8 No. 11 p.79 ~ p.89
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Studies on the Colon Bacillus and Staphylcoccus in the Blood Stream of Rabbits.
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Abstract
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Various factors have been known to affect the course or outcome of microbial infectionsz 1%. However, when the microorganisms are introduced into the blood stream, these factors do not detectably change the early clearance process from the blood stream3 . Thus, it must be that these factors do affect the later stages of the infectious process in the host tissues.
Among these factors, it is conceived, the presence of preexisting infections due to other species of microorganisms, or simultaneous introduction of more than one species of microorganisms into the host tissues, should have effects on the fates of the microorganisms introduced. And species of microorganisms, which constitute of so called normal flora, have been reported to enter the blood stream transiently under the influences of various stresses!´,.
Thus, it was thought that it might be interesting to investigate the later stages of microbial fates in the blood stream, when an exogenous pathogens and a species of normal flora are introduced into the blood stream simultaneously. About 13 X 107 viable units of Es. ´,-coli and/or 12 X 107 viable units of Staph. aureus are introduced intravenously into the ear vein of rabbits and number of viable microorganisms in the heart blood and peripheral blood are followed.
The results obtained might summarized as follows:
1. When Es. coli were introduced intravenously, it resulted a low-grade but persistent bacteremia during the period of 5 hours to 120 hours after inoculation.
2. When Staph. aureus were introduced intravenously, number of viable units in the blood started to increase after about 5 hours. reached the peak number after 48hours, and then decreased, when the animals survived.
3. When Es. coli and Staph. aureus were introduced simultaneously, number of total viable units started to increase after 5 hours and, rate of increase being slow compared to the cases of staphylococcal introduction, reached the peak number after 96 hours.
4. In the cases of mixed inoculation, viable units of Es. coli or Staph. aureus were less than those in the cases of inoculation of Es. coli or Staph. aureus.
5. Ill the cases of mixed inoculation, the peak number of total of total viable _.units were less than the peak number of viable units in the cases of staphlococcal inoculation.
6. Viable organisms in the peripheral blood were less than those in the heart blood.
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