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KMID : 0378019830260120183
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New Medical Journal
1983 Volume.26 No. 12 p.183 ~ p.187
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Clinical Trials of Ranitidine for the Short-Term Treatment of Acute Gastritis in comparison with Conventional Antacid Therapy
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Abstract
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56 cases of acute gastritis who were admitted at Paik Hospital in Busan from January to August, 1983 were divided into 2 groups, namely the first group, 34 cases were prescribed Ranitidine alone, and the second group, 22 cases were treated with conventional antacid.
All 56 cases were evaluated endoscopically with 1 week interval for 3 weeks.
The results were following;
1) Male to Female ratio in acute gastritis was 1. 4 : 1 and the highest incidence was 4th decade.
2) The main symptoms of acute gastritis were epigastric pain (89.3%) nausea (78.6%), vomiting (60.7%). anorexia, diarrhea, indigestion, hematemesis, and melena in order of their frequency.
3) Unhygienic meal taking as external factor, and liver cirrhosis with variceal bleeding as internal factor were chief etiological factors for acute gastritis.
4) In the group of Ranitidine treatment, epigastric pain was subsided in 80.6% after 2 weeks, in 90.3% after 3 weeks, but, in the control group, in 26. 3% after 2 weeks, in 84.2% after 3 weeks, respectively. Also the other symptoms were improved more rapidly in Ranitidine group than in the control group,
5) The side effects of Ranitidine were noted in 3 cases, 2 cases of constipation and 1 case of smnolence. However, these symptoms were not severe enough to discontinue the medication.
In conclusion, Ranitidine appeared to be effective and safe for the short-term treatment of acute gastritis.
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