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KMID : 0378020080510010048
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New Medical Journal
2008 Volume.51 No. 1 p.48 ~ p.55
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Role of Molecular Imaging in Cancer Diagnosis
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Jeon Tae-Joo
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Abstract
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Molecular imaging is emerging field dealing with visualization of biology of living organism by imaging the location and expression levels of specific genes and proteins that control various diseases. Despite the rapid evolution of many anatomic imaging modalities such as US, CT, and MRI, early detection of malignant lesion in human using these tools
faced serious difficulties because carcinogenesis is sub-cellular process preceding anatomic change. Therefore, applying of molecular imaging to this field is essential to improve the results of early detection and proper treatment of cancer. In some aspects, magnetic resonance imaging (MRI), single photon emission computerized tomography (SPECT) and positron emission tomography (PET) also can perform the molecular imaging roles using various gene or protein targeted contrast agents or radiotracers but optical imaging using CCD camera is one of the most important molecular imaging tools and can play a crucial role in depiction of target gene and cancer related molecules as well as cancer treatment. Furthermore, recent big progression in reporter gene study is facilitating the development of molecular imaging and there is no doubt in rapid expansion of this field in the near future.
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KEYWORD
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Molecular Imaging, Cancer Diagnosis, Reporter gene
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