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KMID : 0378119830100010069
Chungnam Medical Journal
1983 Volume.10 No. 1 p.69 ~ p.72
The Influence of 6-Hydroxydopamine on the Centrally Induced Pressor Action of Substance P


Abstract
In this study we investigated whether the effects of intracranioventricular substance P involve central catecholaminergic system.
Intracranioventricular substance P (10 ng/kg) increased blood pressure but heart rate was changed variably.
The central pressure response of substance P is markedly attenuated by intracranioventricular pretreatment with 6-hydroxydopamine (500 mg/kg).
From the above results, it is suggested that the central pressure response of substance P involve central catecholaminergic system.
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