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KMID : 0378119840110010218
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Chungnam Medical Journal
1984 Volume.11 No. 1 p.218 ~ p.228
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Characteristics of Renin Relase in Two-kidney, One-clip Goldblatt Hypertensive Rats
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Abstract
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It has long been suggested that the change of renin-angiotensin system is responsible for the increased arterial blood pressure in experimental hypertension. But the exact nature of the cause and maintenance. of early and late phase of renal hypertension is still controversial.
To clarify the nature of the renin release in both clipped and non-clipped kidney of two-kidney,one-clip Goldtlatt hypertensive model, in vitro slice experiments have been done in rats. Experiments were carried out in the rats of 3,7, and 35 days of operation.
Percent release of lenin from the clipped kidney was suppressed compared to its corresponding sham-operated and control rats. Percent release of lenin from the untouched non-clipped kidney3 to 7 operation days of rats was much more suppressed than the clipped kidney. The responsiveness of the 3 and 7 days non-clipped kidney to the beta-receptor aganist, isoproterenol, was accentuated by 290 and 210 percent respectively, while the increments of the clipped kidney were not different from its corresponding sham-operated and control rats. nenin suppression of clipped and non-clipped kidney by angiotensin ll was attenuated compared to its control rats hut the rew as no differences between both kidneys of Goldblatt rats.
These data suggest that the renin response to beta-receptor aganist, isoproterenol, has been accentuated in the non-clipped kidney by some changes in adrenergic beta-receptor or intracellular renin pools, and that the negative feedback control mechanism controlling lenin-angiotensin system by angiotensin has teen attenuated in two-kidney, one-clip Gldblatt hypertensive rats.
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