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KMID : 0379220090290020657
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Journal of Korea Gerontological Society
2009 Volume.29 No. 2 p.657 ~ p.667
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The Effect of Swimming Exercise on Telomere Length & Expression of Telomere Repeat Binding Factor 2 in Rats
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Kim Sang-Hoon
Lee Jeong-Pil
Yoon Jin-Ho
Oh Jae-Keun
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Abstract
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The aim of the present study was to investigate the effects of swimming exercise on growth-related telomere length and expression of TRF 2 in different tissues of SD rats. The telomere lengths of all the tissues analyzed were longer in the standard group than either in aged-control group or in two aged-exercise groups, suggesting growth-induced attrition of telomere lengths. On the other hand, it was also found that swimming exercise could attenuate this growth-related telomere attrition in the heart tissue of the long-term group only, with no significant attenuating effects of aerobic exercise on either liver telomere length or soleus muscle telomere length. Also, in the heart, TRF 2 expression was significantly lower in control group compare to standard group. But, there was significantly higher in long term exercise group compare to control group. There was positive correlation between telomere length and expression of TRF 2 in heart tissue. This study implies that the swimming exercise performed for longer periods of time can contribute to growth process of heart by regulation of telomere length and TRF 2 expression. In the growth process, the regular swimming exercise will provide a meaningful advantage for various physiological processes.
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KEYWORD
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aging, telomere, TRF2, swimming
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