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KMID : 0380019950100010097
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Korean Journal of Biotechnology and Bioengineering
1995 Volume.10 No. 1 p.97 ~ p.103
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Process Simulation for the Production of Porcine Growth Hormone Using CAD Program
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Abstract
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A computer simulation of biochemical process was carried out using Macintosh-based BioDesignerT" developed at Bioprocess and Engineering Center(BPEC) of MIT. Based on the assumptions and flask culture experiments, a porcine growth hormone(PGH, Porcine Somatotropin) production procss was simulated by a two-stage continuous culture. The economical and sensitivity analyses were evaluated for the scale-up production of PGH. A high return on investment(ROI, 104%/year) suggested that the process be profitable. Howeve;sensitivity analysis indicated that ROI was dependent on the yield of PGH, selling price, dose and the achievement of projected market penetration.
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