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KMID : 0380020040190010067
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Korean Journal of Biotechnology and Bioengineering
2004 Volume.19 No. 1 p.67 ~ p.71
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Antioxidant Activity of Rosa rugosa
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Seo Young-Wan
Lee Hee-Jung
Ahn Jong-Woong
Lee Bum-Jong
Moon Sung-Gi
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Abstract
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An antioxidant activity of Rosa rugosa extract and its solvent-partitioned fractions was determined not only by measuring lipid peroxide produced when a mouse liver homogenate was exposed to the air at 37, using thiobarbituric acid (TBA) but also by evaluating the free radical scavenging effect against DPPH radical, authentic peroxynitrite, and 3-morpholinsydnonimine (SIN-1). All its partitioned fractions including crude extract showed potent scavenging effect against DPPH radical, peroxynitrite, and lipid peroxidation. n-BuOH fraction, in particular, was found to be the most effective in DPPH radical scavenging ability as well as inhibition against lipid peroxidation. The 15% aqueous MeOH fraction also showed a strong potency which was slightly lower than n-BuOH fraction. Based on these results, we suggest that Rosa rugosa could be useful for preventing an oxidative damage.
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KEYWORD
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Rosa rugosa, peroxynitrite, DPPH, radical scavenging activity, lipid peroxidation
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