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KMID : 0380020060210060484
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Korean Journal of Biotechnology and Bioengineering
2006 Volume.21 No. 6 p.484 ~ p.488
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Separation of 6-Gingerol from Ginger [Zingiber officinale Roscoe] and Antioxidative Activity
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Lee Bong-Soo
Ko Meyong-Seok
Kim Hyun-Jong
Kwak In-Seob
Kim Dong-Ho
Chung Bong-Woo
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Abstract
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Ginger (Zingiber officinale) is widely used as a dietary condiment throughout the world. Its major constituent, 6-gingerol, exhibits diverse pharmacological activities including anti-oxidant and anti-tumor. Ginger were extracted by 0% to 95% ethanol. Maximum yield of 6-gingerol was obtained with 80% ethanol as extracting solvent at . We obtained increased yield (7%) of extraction by pretreatment with ultrasonication. Gingerols in the crude ginger extract was isolated by Sepacore preparative liquid chromatography on silica gel. We got the 6-gingerol which weight is 0.53 mg/mL, from fraction F9. Antioxidant effect of 6-gingerol were detected by DPPH moth(10. Its radical scavenging activity was which compared with ascorbic acid.
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KEYWORD
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Ginger, 6-gingerol, extraction with ultrasonication, antioxidative activity
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