|
KMID : 0380020090240030239
|
|
Korean Journal of Biotechnology and Bioengineering
2009 Volume.24 No. 3 p.239 ~ p.245
|
|
|
Microbial styrene monooxygenase-catalyzed asymmetric synthesis of enantiopure styrene oxide derivatives
|
|
Lee Eun-Yeol
Park Sung-Hoon
|
|
|
Abstract
|
|
|
|
Enantiopure styrene oxide derivatives are versatile building blocks for the synthesis of enantiopure pharmaceuticals. Styrene monooxygenase (SMO) catalyzes an asymmetric addition of an oxygen atom into a double bond of vinylaromatic compounds. SMO is a commercially potential biocatalyst to synthesize a variety of enantiopure epoxides with high enantiopurity and recovery yield. In this paper development of SMO biocatalyst and commercial feasibility of SMO-catalyzed asymmetric synthesis of enantiopure stylers oxide derivatives are reviewed.
|
|
|
KEYWORD
|
|
|
enantiopure epoxides, enantiopure styrene oxide, asymmetric synthesis, monooxygenase, stylers monooxygenase
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|