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KMID : 0380020110260020100
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Korean Journal of Biotechnology and Bioengineering
2011 Volume.26 No. 2 p.100 ~ p.106
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Characterization of an Indigenous Antimicrobial Substance-producing Paenibacillus sp. BCNU 5011
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Choi Hye-Jung
Kim Ya-Ell
Bang Ji-Hun
Kim Dong-Wan
Ahn Cheol-Soo
Jeong Yong-Kee
Joo Woo-Hong
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Abstract
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Strain BCNU 5011 was isolated from forest soil samples collected in the Taebaek mountain in the Gangwon province, Korea. The biochemical, physiological and 16S rRNA sequence analysis strongly indicated that this isolate was most closely related to Paenibacillus polymyxa. A maximum production level of antimicrobial substances of Paenibacillus sp. BCNU 5011 was achieved under aerobic incubation at 30℃for 3 days in SST broth.Paenibacillus sp. BCNU 5011 showed a broad spectrum of activity against Gram positive and Gram negative bacteria, including methicllinresistant Staphylococcus aureus (MRSA). Paenibacillus sp. BCNU 5011 was also shown to inhibit the growth of different potential human pathogenic bacteria and fungi in vitro. Peptide extract showed better antimicrobial activity than solvent extracts. But active antimicrobial compounds might be included in both peptide extract and solvent extracts. Further separation, purification and identification of active principles leads project to develop antimicrobial agents and anti-MRSA agents
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KEYWORD
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Paenibacillus polymyxa, Antimicrobial activity, Human pathogenic fungi, Methicllin-Resistant Staphylococcus aureus
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