KMID : 0380020120270060375
|
|
Korean Journal of Biotechnology and Bioengineering 2012 Volume.27 No. 6 p.375 ~ p.380
|
|
The Evaluation of Antithrombotic and Fibrinolytic Activities of Nattokinase from Bacillus subtilis Natto
|
|
Lee Da-Lyung
Hong Sung-Yu Jang Yang-Su Jang Hyung-Wook Maeng Chang-Jae Yoo Chul-Bae Baek Dae-Heoun
|
|
Abstract
|
|
|
We previously reported that Ultra nattokinase¨Þ showed high fibrinolytic activity and revealed antithrombotic effect in rat blood plasma based on its ability to suppress collagen-induced platelet aggregation. This research was carried out to verify the clot lysing activity and blood flow enhancing effects of Ultra nattokinase¨Þ via monitoring and comparing the antithrombotic effects in rat artery between oral administration of Ultra nattokinase¨Þ and maltodextrin. SD rats were fed with 1.11 mg/kg of Ultra nattokinase¨Þ for 4 weeks. The effect on arterial thrombosis was then evaluated using an antithrombotic model after induction by FeCl3. Detected fibrinolytic activity was proportional to the content of Ultra nattokinase¨Þ and statistical extents of the antithrombotic activity was enhanced strongly twice rather than control group. The PT and the aPTT, however, showed only a small difference between two groups. The results suggest that Ultra nattokinase¨Þ can effectively treat thromboembolism and enhance blood flow, and that Ultra nattokinase¨Þ can also prevent venous occlusion by aiding clot lysis.
|
|
KEYWORD
|
|
Bacillus subtilis Natto, Ultra nattokinase(R), Antithrombotic effect, Fibrinolytic effect, Platelet aggregation
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|