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KMID : 0380020160310020126
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Korean Journal of Biotechnology and Bioengineering
2016 Volume.31 No. 2 p.126 ~ p.134
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Antiaging Effects of Musa sapientum L. (Banana) Leaf Extract
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Yoo Dae-Sung
Jang Su-jin
Park Yun-Jeong
Kim Seung-Hoi
Hwang Hyung-Seo
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Abstract
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To examine the possibility of using Musa sapientum L. (Banana) leaf extract as a cosmetic raw material, banana leaves grown in Jeju Island were extracted with 70% ethanol. Polysaccharides present in banana leaf extract were discarded by precipitation with cold ethanol. Polysaccharidediscarded banana leaf extract promoted procollagen and COL1A1 gene expression, but inhibited matrix metalloproteinase (MMP)-1 and MMP-2 gene expression in human skin fibroblasts when examined by real-time reverse-transcription polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA). The active compound in banana leaves was identified by fractionation with various solvents. The chloroform fraction showed the highest anti-wrinkle efficacy and the active compound of chloroform fraction was identified as corosolic acid by NMR, FT-IR, EA, and HPLC-MS. In addition, banana leaf extract showed anti-oxidative efficacy with an IC50 value of 67.91 ppm, as determined by DPPH free radical scavenging assay. Finally, the anti-wrinkle efficacy of banana leaf extract-containing cream was confirmed by clinical tests. Based on these results, banana leaves could have an application as a cosmetic raw material with anti-wrinkle efficacy.
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KEYWORD
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Musa sapientum L. leaves, Corosolic acid, Antiaging, Anti-wrinkle
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