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KMID : 0380020210360040254
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Korean Journal of Biotechnology and Bioengineering
2021 Volume.36 No. 4 p.254 ~ p.259
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Developments of GABA Process for the Mass Production
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Kim Eui-Jin
Shin Hyun-Jae
Lee Jung-Heon
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Abstract
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Gamma-amino butyric acid (GABA) is a component of pharmaceuticals and functional foods. GABA can be biosynthesis through the decarboxylation of glutamate by glutamate decarboxylase (GAD) and this conversion process consume hydrogen ion cause change pH condition. Mass production of GABA process overcome changing pH, supplied HCl each 3 hr when 3 times for prevent pH shift and using 1 M HCl for the inhibition to destroying of GAD structure and added PLP for increasing to GAD activity developed process of mass production that 1M MSG convert to 0.99 M GABA on 15 hour. Consider to GAD activity and produced GABA purity, this process is suitable for mass production process of GABA.
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KEYWORD
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gamma-amino butyric acid, glutamate decarboxylase, monosodium glutamate, mass production process
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