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KMID : 0380420010250020073
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Journal of Prventive Veterinary Medicine
2001 Volume.25 No. 2 p.73 ~ p.81
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Effect of Ethanol on Circulating Mg2+ Concentration and Mg2+ Extrusion
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Abstract
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Alcohol abuse is associated with a change in cellular electrolyte homeostasis. We investigated the changes in plasma and extracellular Mg2+ content and the protective effect of melatonin against changes in Mg2+ content in ethanol treated rats. The acute administration of ethanol to anesthetized rats resulted in an increase in plasma Mg2+ levels. As expected, the acute administration of ethanol mobilized a considerable amount of Mg2+ from perfused rat livers and hearts,indicating that organs have a major pool of Mg2+ which can be induced by ethanol. These acute ethanol-induced Mg2+release from perfused livers and hearts were inhibited by melationin. Also, acute ethanol administration in vivo produced an increase in urinary volume and urinary Mg2+ extrusion, and a decrease in plasma Mg2+ content in a dose-dependent fashion. Chronic ethanol feeding to rats for 4wk resulted in a decrease in plasma Mg2+ content and liver/body weight ratio. The heart/body weight ratio and the body weight gain, however, did not differ significantly between control and ethanol groups. This ethanol-induced decrease in Mg2+ content was reversed by combination-fed of melatonin or MgCl2. These results suggest that alcohol ingestion is associated with abnormalities in circulating or cellular Mg2+ concentration and that melatonin supplementation might attenuate ethanol-induced Mg2+ extrusion.
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