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KMID : 0380420140380010007
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Journal of Prventive Veterinary Medicine
2014 Volume.38 No. 1 p.7 ~ p.14
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Dietary turmeric presents mild immune suppressing and anti-inflammatory effects
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Kim Yun-Mi
Lee Jin-A
Kim Tae-Hoon
Jung Bock-Gie
Lee Bong-Joo
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Abstract
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Pathologic chronic inflammation, such as that seen with microbial infection and autoimmune diseases, creates microenvironmental conditions that promote cancer. Therefore, if chronic inflammation can be alleviated, the risk of carcinogenesis may decrease. Turmeric is a dried rhizome powder from Curcuma longa. Curcumin, the major constituent of turmeric, presents anti-inflammatory, antioxidant, antimicrobial, and chemopreventive activities. In the present study, we investigated immune responses to dietary turmeric in ICR mice to determine the effects of turmeric when used as a dietary chemoprevention agent. After dietary turmeric was given for three or six weeks to ICR male mice, the immune responses were characterized. The methods of characterization involved; the determination of the T cell subpopulation in the spleen, relative mRNA expression levels of IFN-γ and TNF-α, and serum lysozyme activity. Dietary turmeric was found to decrease spleen weight, decrease the proportion of CD4-CD8+ T cells, and decrease phagocytic activity. These results suggest that turmeric might alleviate abnormal chronic inflammation by the action of immune suppression.
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KEYWORD
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Turmeric, Curcuma Longa, curcumin, Immune-suppressing effects
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