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KMID : 0380420200440040201
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Journal of Prventive Veterinary Medicine
2020 Volume.44 No. 4 p.201 ~ p.206
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Cytotoxicity evaluation of different commercially available absorbent feminine hygiene products and a transdermal patch using direct contact and extract exposure methods
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Reyes Alisha Wehdnesday Bernardo
Huy Tran Xuan Ngoc
Vu Son Hai
Nguyen Trang Thi
Min Won-Gi
Lee Hu-Jang
Kim Suk
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Abstract
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We investigated the cytotoxic potential of three different commercially available absorbent feminine hygiene products and one transdermal patch using direct contact and extract exposure methods. Two different cell lines were used ? mouse fibroblast L929 and normal human skin fibroblast CCD-986sk cell lines. The test samples were extracted using three different methods in accordance to International Organization for Standardization (ISO). Viability of cells was analyzed using MTT assay and morphology of the cells were also observed using phase contrast microscopy. Overall, the direct contact method using L929 cells showed that all the test samples had no toxic effect when exposed to extracts for 1 h. For the exposure method, no toxic effect was observed in both L929 and CCD986sk cells incubated with all the test samples regardless of the extraction methods used.
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KEYWORD
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CCD-986Sk, cytotoxicity, L929, sanitary pad, transdermal patch
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