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KMID : 0381120070290030275
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Genes and Genomics
2007 Volume.29 No. 3 p.275 ~ p.284
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Use of Caenorhabditis elegans as a Genetic Model for Bacterial Pathogenesis Studies
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Emad Abd-elmoniem Abada
Mohamed El-sayied Osman
Jaya Bandyopadhyay
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Abstract
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The nematode, Caenorhabditis elegans is emerging as an attractive genetic model for the study of host-pathogen interactions. C. elegans is killed by several pathogenic organisms like Pseudomonas aeruginosa, Serratia marcescens, Salmonella enterica, Staphylococcus aureus, and Vibrio cholerae. A number of virulence mechanisms used by these pathogens have been found to be significant for disease manifestation in C. elegans, including colonization with biofilm
formation on the worm cuticle, persistent infection of intestine, and killing by toxins. Microbial virulence factors such as the quorum-sensing systems or the Gram-negative type III secretion systems are important for worm killing. There exists a high degree of conservation in the mechanistic pathways associated with the disease manifestations, and as well high
degree of overlap between the virulence factors required for pathogenesis in the nematodes and the humans, therefore increasing the significance of model organisms such as C. elegans to the drug discovery process.
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KEYWORD
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Caenorhabditis elegans, bacterial pathogenesis, drug discovery
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