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KMID : 0381120110330020133
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Genes and Genomics
2011 Volume.33 No. 2 p.133 ~ p.133
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Association of the vascular endothelial growth factor (VEGF-1154G>A) polymorphism in patients with colorectal cancer
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Choi Yi-Seul
Choi Jeong-Kwon
Kim Jong-Woo
Min Kyung-Tae
Kwon Young-Do
Jang Moon-Ju
Chong So-Young
Oh Do-Yeun
Cho Yoon-Kyung
Hong Seung-Ho
Kim Nam-Keun
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Abstract
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Angiogenesis plays a pivotal role in the development of colon cancer during the promotion and metastasis of tumor growth. Vascular endothelial growth factor (VEGF) is known to be a potent angiogenic factor. This hospital-based case-control study was carried out to decide where there existed an association between the VEGF-1154G>A polymorphism and the susceptibility to colon cancer. DNA samples taken from 278 colon cancer patients and 226 healthy controls were studied using with real-time PCR for VEGF-1154G>A polymorphism. Genotype frequencies of the VEGF-1154G>A polymorphism were significantly different between patient and control groups (adjusted OR=2.735, 95% CI=1.243?6.015 for AA vs. GG genotype). In addition, upon stratification by gender and age, the frequencies of the A allele-bearing genotypes significantly increased the risk for development of colon cancer in men and patients younger than 55 years (in men, adjusted OR=3.375, 95% CI=1.062?10.717, and in <55 years, adjusted OR=4.908, 95% CI=1.294?18.617). Also, upon stratification of patients with proximal and distal colon cancer individually, the association only showed these significant patterns in distal colon cancer. This study provides evidence that VEGF-1154G>A polymorphism, at least in Koreans, might be associated with risks of the colon cancer, particularly in males.
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KEYWORD
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Colon cancer, Vascular endothelial growth factor (VEGF), Polymorphism, Korean
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