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KMID : 0381120200420121381
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Genes and Genomics
2020 Volume.42 No. 12 p.1381 ~ p.1387
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Molecular subtypes of triple-negative breast cancer: understanding of subtype categories and clinical implication
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Lee Yong-Moon
Oh Man-Hwan
Go Jai-Hyang
Han Kyu-Dong
Choi Song-Yi
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Abstract
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Background: Triple-negative breast cancer (TNBC) is a heterogeneous entity that encompasses several subtypes with distinct molecular characteristics. The patients with TNBCs show unpredictable response to the chemotherapy, and further there is the lack of effective agents. Thus, many studies have been underway to discover targeted therapy suitable for patients with specific genetic alterations in each molecular subtypes. TNBCs are classified as four major molecular subtypes according to the gene expression patterns. These are luminal androgen receptor (LAR), mesenchymal-like, immunomodulatory (IM), and basal-like types.
Conclusion: Here, we discuss the unique molecular features of each subtype as well as promising targets for anti-cancer therapy.
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KEYWORD
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Triple negative breast cancer, Breast cancer, Molecular diagnosis, Precision medicine
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