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KMID : 0381919930230030144
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Korean Journal of Microscopy
1993 Volume.23 No. 3 p.144 ~ p.158
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Ultrasturctural Study on the Growth of Phalangeal Cartilage Allografts into the Cerebral Hemisphere of The Mongolian Gerbil
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Abstract
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In order to investigate the osteogenesis at the epiphyseal plate in a non-functional environment, allograft of embryonic phalanges into the cerebral hemisphere of adult Mongolian gerbil was performed. Light and electron microscopic observations were made at intervals of one week to eight weeks following the implantation.
The typical arrangement of the cell columns was observed in the epiphyseal plate and both endochondral and subperiosteal ossification until three weeks after implantation. In the embryonic phalanges, the processes of initial osteogenesis in diaphysis were observed to possess morphological similarities to that occurring at the metaphyseal side of the epiphyseal plate. Periosteal new bone was present in all graft phalanges with periosteum. Resorption of mineralized cartilagenous septa was undertaken by multinucleated chondroclasts. The longitudinal bone growth proceeded progressively and following the transplantation attained maximum length at seven weeks but eventually became hollw ossicle of new bone after eight weeks.
Irregularity of the cell columns arid disintegration of the periosteum were noted at four weeks. Endochondral ossification of the epiphysis and epiphyseal plate could be traced up to six weeks. Articular cartilage and epiphyseal plate disappeared partially at six weeks. Most of terminal hypertrophied chondrocytes of the articular cartilage and epiphyseal plate remained viable after they became embedded in mineralized cartilagenous septa.
These results suggest that the hypertrophied chondrocytes of the calcified cartilage of an embryonic bone are transformed into osteoblasts and osteocytes which from endochondral.
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