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KMID : 0381920080380030245
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Korean Journal of Microscopy
2008 Volume.38 No. 3 p.245 ~ p.250
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Vitamin C Enhances the Effect of Etoposide to Inhibit Human Prostate Cancer Growth in vitro
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Lee Myeong-Seon
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Abstract
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Etoposide (Eto) is chemotherapeutic compounds that is currently used in the treatment of metastatic prostate cancer but new therapeutic agents are needed for the treatment of androgen-independent prostate cancer. The objective of the present study was to determine whether vitamin C (VC), the antioxidant, plays a role in regulating the growth of prostate cancer cell lines and whether VC has synergistic effect to tumor cell killing by chemotherapeutic drugs. Androgendependent LNCaP and androgen-independent DU-145 prostate cancer cell lines were used in this study. Both cells presented increase of dose- and time-dependent cytotoxicity in Eto-treated cultures. The combined treatment with Eto and VC significantly increased the percentage of apoptotic cells compared to Eto-treated cells (p?0.05). The present findings demonstrated that VC inhibited the growth of prostate cancer cell lines by Eto-mediated cytotoxicity and induced apoptosis. These results suggest that the chemotherapeutic effect of Eto on prostate cancer can be enhanced by VC.
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KEYWORD
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Prostate cancer, Apoptosis, Etoposide, Vitamin C
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