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KMID : 0381920080380040375
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Korean Journal of Microscopy
2008 Volume.38 No. 4 p.375 ~ p.382
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The Shape of Synaptic Vesicles in the Tooth Pulp Afferent Terminals and P-endings in the Rat Trigeminal Nucleus Principalis
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Kim Yun-Sook
Paik Sang-Kyoo
Kwak Woo-Kyung
Cho Yi-Sul
Kim Ji-Man
Park Mae-Ja
Bae Yong-Chul
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Abstract
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In order to investigate shape of synaptic vesicles of the tooth pulp afferent boutons and their presynaptic endings (pendings), and the neuroactive substance of the p-endings in the trigeminal nucleus principalis, rat incisor tooth pulp afferents were labeled by the horseradish peroxidase (HRP) and quantitative ultrastructural analysis and postembedding immunogold labeling were performed. Labeled tooth pulp afferent boutons contained clear, spherical synaptic vesicles (diameter: 45~55 nm) and occasionally dense core vesicles(diameter: 80~120 nm). They formed symmetrical synapses with unlabeled axon terminals (p-endings) containing pleomorphic synaptic vesicles. The ratio of short to long diameter (form factor) of synaptic vesicles of pulp afferent boutons was 0.6 to 0.99, whereas that of p-endings was 0.25 to 0.99. In addition, most of the pendings showed GABA-like immunoreactivity. These results indicate that the shape of synaptic vesicles is quite different between the tooth pulp afferent boutons and p-endings, and the p-endings may contain GABA as a neuroactive substance in the trigeminal nucleus principalis.
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KEYWORD
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Tooth pulp, Primary afferents, Trigeminal, Ultrastructure, Synapse
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